| 潘佳慧,王颖,姜宜萱,刘怡萱,赵琦,王静夷.基于ELSA队列的英格兰不同年龄段中老年人认知功能变化长期预测因素10年随访研究[J].老年医学与保健,2025,31(6):1484-1497 |
| 基于ELSA队列的英格兰不同年龄段中老年人认知功能变化长期预测因素10年随访研究 |
| Ten-year follow-up study on long-term predictors of cognitive function changes in middle-aged and elderly people of different age groups in England based on ELSA cohort |
| |
| DOI：10.3969/j.issn.1008-8296.2025.06.016 |
| 中文关键词: 认知功能 中老年人 预测因素 年龄分层 |
| 英文关键词: cognitive function middle-aged and elderly predictive factor age stratification |
| 基金项目:72104053:国家自然科学基金 |
|
| 摘要点击次数: 332 |
| 全文下载次数: 217 |
| 中文摘要: |
| 目的 探讨不同年龄段中老年人群认知功能变化的长期预测因素.方法 基于英国老龄化纵向研究(ELSA)数据库中第4 与第9 轮调查数据,根据年龄分层,对 5 616 名研究对象 10 年间认知功能衰退的长期影响因素进行分析.结果 男性、日常生活活动能力受限、抑郁、身体活动水平低及其与时间的交互作用是各年龄段中老年人认知功能下降的危险因素,而受教育程度高、家庭财富较多、白人种族、社会网络良好和适度饮酒对认知功能有保护作用.在60 岁以下人群中,年龄增长和严重视力问题加速认知退化,且认知下降呈现随年龄加速的非线性趋势;而较高的税后收入则为保护因素.在60 岁及以上人群中,年龄及其与时间的交互作用、高血压、脑卒中、帕金森病和听力障碍是认知功能下降的危险因素.结论 认知功能的长期影响因素存在明显的年龄差异.对 60 岁以下人群,应聚焦教育提升、慢性病早期防控、身体活动促进和社会心理支持;对高龄人群,在落实上述干预的基础上,需进一步加强对慢性病的综合管理,制定多维度、分阶段的认知健康干预策略. |
| 英文摘要: |
| Objective To explore the long-term predictors of cognitive function changes in middle-aged and elderly people of different age groups.Methods Based on the data from the 4th and 9th rounds of surveys in the English Longitudinal Study of Ageing(ELSA)database,the long-term influencing factors of cognitive decline in 5 616 research subjects over a 10-year period were analyzed according to their age stratification.Results Male gender,limitations in activities of daily living,depression,low levels of physical activity,and their interaction with time were risk factors for cognitive decline across all age groups.In contrast,higher educational levels,greater household wealth,white race,strong social networks,and moderate alcohol consumption had protective effects on cognitive function.In the population under the age of 60,aging and severe vision problems accelerated cognitive decline,and the cognitive decline showed a non-linear and age-accelerated trend.On the other hand,higher after-tax income served as a protective factor.In the population aged 60 and above,age and its interaction with time,hypertension,stroke,Parkinson's disease,and hearing impairment were identified as risk factors for cognitive decline.Conclusion There are significant age-related differences in the long-term factors influencing cognitive function.For the population under the age of 60,interventions should focus on enhancing education,early preventing and controlling chronic diseases,promoting physical activity,and providing psychosocial support.For the elderly,in addition to the above interventions,comprehensive management of chronic diseases should be strengthened,and multidimensional and staged intervention strategies for cognitive health should be developed. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
