| 刘兆杰,石珏,舒锦.增强型体外反搏对老年射血分数保留的心力衰竭患者生活质量的影响[J].老年医学与保健,2025,31(6):1527-1532 |
| 增强型体外反搏对老年射血分数保留的心力衰竭患者生活质量的影响 |
| Effects of enhanced extracorporeal counterpulsation on quality of life of elderly patients with preserved ejection fraction heart failure |
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| DOI：10.3969/j.issn.1008-8296.2025.06.022 |
| 中文关键词: 老年 增强型体外反搏 射血分数保留型心力衰竭 生活质量 心功能 |
| 英文关键词: elderly enhanced extracorporeal counterpulsation preserved ejection fraction heart failure quality of life cardiac function |
| 基金项目:2022QN006:上海市卫生健康委员会中医药科研项目;2024ZD03:上海市静安区医学重点学科建设项目;2022ZX01:上海市静安区卫生科研课题中西医结合项目 |
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| 中文摘要: |
| 目的 研究增强型体外反搏(EECP)对老年射血分数保留的心力衰竭(HFpEF)患者生活质量的影响.方法 2023 年5 月至2024 年5 月,选取上海市静安区市北医院老年科住院的老年HFpEF患者80 例,将受试者随机分为对照组(n=40)和EECP组(n=40).对照组患者予心衰常规药物治疗,EECP组患者在对照组口服药物的基础上联合EECP治疗,治疗12 周.比较2 组治疗前后的6 min步行测试(6-MWT);血清脑钠肽(BNP)、生长刺激表达基因2 蛋白(ST2)表达水平;左室射血分数(LVEF)、左心室舒张末内径(LVEDD)、左心室收缩末内径(LVESD)和明尼苏达心力衰竭生活质量问卷(MLHFQ)评分.结果 与对照组相比,EECP组治疗后6-MWT较长,血清BNP、ST2 水平较低,LVEDD、LVESD较小,MLHFQ评分较低,差异有统计学意义(P＜0.05).与对照组相比,EECP组治疗前后的6-MWT,血清BNP、ST2,LVEF、LVEDD、LVESD以及MLHFQ评分差值较大,差异有统计学意义(P＜0.05).结论 辅助EECP治疗能一定程度改善老年HFpEF患者的心功能及生活质量,但对心脏结构的改善并不明显. |
| 英文摘要: |
| Objective To investigate the effects of enhanced extracorporeal counterpulsation(EECP)on the quality of life of elderly patients with preserved ejection fraction(HFpEF)heart failure.Methods From May 2023 to May 2024,80 elderly HFpEF patients admitted to Department of Geriatrics,Shibei Hospital,Jing'an District were selected and randomly divided into control group(n=40)and EECP group(n=40).The control group received routine medication for heart failure,while the EECP group received EECP treatment in addition to the routine medication.Both groups were treated for 12 weeks.The following parameters were compared between the two groups before and after treatment:6-minute walk test(6-MWT);serum levels of brain natriuretic peptide(BNP)and growth stimulation expressed gene 2 protein(ST2);left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD);and Minnesota living with heart failure questionnaire(MLHFQ)score.Results Compared with the control group,the EECP group showed a significantly longer 6-MWT distance,lower serum levels of BNP and ST2,smaller LVEDD and LVESD,and a lower MLHFQ score after treatment,with statistically significant differences(P＜0.05).Compared with the control group,the differences in 6-MWT,serum BNP,ST2,LVEF,LVEDD,LVESD and MLHFQ scores before and after treatment in the EECP group were larger,and the differences were statistically significant(P＜0.05).Conclusion Adjunctive EECP therapy can improve cardiac function and quality of life to some extent in elderly HFpEF patients,but its effect on cardiac structure is not significant. |
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