| 王鹏程,张记君,李媛睿,马玲梅.Toll样受体4/核因子κB信号通路对神经介入术联合静脉溶栓治疗脑梗死预后影响的机制研究[J].老年医学与保健,2026,32(3):394-398 |
| Toll样受体4/核因子κB信号通路对神经介入术联合静脉溶栓治疗脑梗死预后影响的机制研究 |
| Mechanism study of effects of Toll-like receptor 4/nuclear factor-kappa B signaling pathway on prognosis of patients with cerebral infarction treated by neurointerventional surgery combined with intravenous thrombolysis |
| |
| DOI：10.3969/j.issn.1008-8296.2026.03.013 |
| 中文关键词: Toll样受体4/核因子-κB通路 神经介入术 静脉溶栓 脑梗死 神经功能 |
| 英文关键词: Toll-like receptor 4/nuclear factor-κB pathway neurointerventional surgery intravenous thrombolysis cerebral infarction neurological function |
| 基金项目:202203021232368:山西省基础研究计划项目 |
|
| 摘要点击次数: 331 |
| 全文下载次数: 163 |
| 中文摘要: |
| 目的 探讨 Toll 样受体4(TLR4)/核因子-κB(NF-κB)信号通路对神经介入术联合静脉溶栓治疗脑梗死(IS)预后影响的机制.方法 回顾性分析2023 年11 月至2025 年5 月阳泉市第一人民医院110 例IS 患者临床资料,分为对照组(单纯静脉溶栓,n=55)和介入组(神经介入术联合静脉溶栓,n=55).比较 2 组患者美国国立卫生研究院卒中量表(NIHSS)、改良 Rankin 量表(mRs)评分,TLR4、NF-κB、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)和高敏C 反应蛋白(hs-CRP)等炎症因子水平.结果 治疗 3 个月后,与对照组相比,介入组患者疗效较好(72.73%比 89.09%,P=0.006).与对照组相比,介入组患者治疗前后 NIHSS、mRs 评分,IL-1β、TNF-α、hs-CPR、TLR4、NF-κB 水平差异均有统计学意义(P<0.05).相关性分析显示,血清 TLR4、NF-κB 与 NIHSS、mRs 评分,IL-1β、TNF-α 和 hs-CRP 水平呈正相关(P<0.05).结论 神经介入术联合静脉溶栓治疗 IS 相较于单用静脉溶栓能更有效地抑制 TLR4/NF-κB 信号通路激活与炎症因子水平,改善 IS 患者神经功能. |
| 英文摘要: |
| Objective To explore the effects of the Toll-like receptor 4(TLR4)/nuclear factor-κB(NF-κB)signaling pathway on the prognosis of patients with cerebral infarction treated by neurointerventional surgery combined with intravenous thrombolysis,as well as its mechanism.Methods The clinical data of 110 patients with cerebral infarction treated in First People's Hospital of Yangquan City from November 2023 to May 2025 were retrospectively analyzed.The patients were divided into control group(simple intravenous thrombolysis,n=55)and intervention group(neurointerventional surgery combined with intravenous thrombolysis,n=55).The National Institutes of Health Stroke Scale(NIHSS)score,modified Rankin Scale(mRs)score,and levels of inflammatory factors including TLR4,NF-κB,interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and high-sensitivity C-reactive protein(hs-CRP)were compared between the two groups.Results After 3 months of treatment,the intervention group showed better clinical efficacy than the control group(89.09%vs.72.73%,P=0.006).Compared with the control group,the differences in the scores of NIHSS and mRs,as well as the levels of IL-1β,TNF-α,hs-CPR,TLR4 and NF-κB before and after treatment in the intervention group were all statistically significant(P<0.05).Correlation analysis revealed that serum levels of TLR4 and NF-κB were positively correlated with the scores of NIHSS and mRs,and with the levels of IL-1β,TNF-α,and hs-CRP(P<0.05).Conclusion Neurointerventional surgery combined with intravenous thrombolysis for cerebral infarction can more effectively inhibit the activation of the TLR4/NF-κB signaling pathway and the levels of inflammatory factors,and improve the neurological function of patients with cerebral infarction compared to intravenous thrombolysis alone. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
